Research & Literature

[Cannabinoids in children] [Article in German] Cannabinoide bei Kindern.

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Reduced pain, spasticity and improved appetite and nausea

A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany.

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The cannabis extract sativex is effective in a large number of patients and well-tolerated in the long-term.

A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men

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Cannabis administration was associated with significant increases in plasma levels of ghrelin and leptin, and decreases in PYY, but did not significantly influence insulin levels

Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers.

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Higher THC concentrations were significantly associated with less difficulty falling asleep and more daytime sleep the following day.

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.

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Cannabidiol (CBD) was shown to be effective in the treatment of epilepsy due to Tuberous sclerosis complex

Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis.

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Effects depended on the ratio of CBD and THC with high CBD reducing appetite enhancing effects of THC.

Cannabidiol enhances consolidation of explicit fear extinction in humans.

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Cannabidiol enhances consolidation of fear extinction in humans.

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.

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Cannabidiol Cannabidiol reduces seizure frequency in epilepsy of children and young adults reduces seizure frequency in epilepsy of children and young adults

Cannabinoid facilitation of fear extinction memory recall in humans.

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THC prevented the recovery of fear in this experiment of extinction learning.

Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study.

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Analysis of specific motor symptoms revealed significant, also sleep and pain improvement after treatment with cannabis.

Cannabis and other illicit drug use in epilepsy patients.

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The use of cannabis did not affect disease severity in epilepsy.

Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report.

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The cannabis extract was effective in a patient with stiff person syndrome.

Cannabis for intractable nausea after bilateral cerebellar stroke.

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A woman with intractable nausea after cerebellar stroke responded well to a treatment with THC.

Cannabis use amongst patients with inflammatory bowel disease.

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Cannabis use is frequent in patients with chronic intestinal inflammation

Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life.

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The use of cannabis was associated with reduction of some fibromyalgia symptoms.

CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience.

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Improvement in behaviour and alertness, language, communication, motor skills and sleep

Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers.

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THC (dronabinol) and smoked cannabis (marijuana) caused similar effects on pain sensitivity and pain tolerance.

Dramatic improvement of refractory Isaacs’ syndrome after treatment with dronabinol.

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Dramathic improvement of symptoms (profuse sweating, muscular twitching, weight loss)

Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms.

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A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite.

Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial.

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THC caused significant improvement in treatment retention and withdrawal symptoms.

Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial.

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THC reduced pain intensity and odynophagia (painful swallowing, in the mouth or oesophagus).

Dronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis.

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THC may be very effective in the treatment of nausea and vomiting in end-stage cancer.

Effect of marijuana use on outcomes in traumatic brain injury.

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A positive THC screen is associated with decreased mortality in adult patients sustaining TBI [traumatic brain injury].

Effective treatment of spasticity using dronabinol in pediatric palliative care.

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In the majority of pediatric palliative patients the treatment with dronabinol showed promising effects in treatment resistant spasticit.

Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial

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Significant improvement in well-being. No effects on motor functioning or neuroprotection.

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population.

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Migraine headache frequency on average decreased from 10.4 to 4.6 headaches per month with the use of cannabis.

Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial.

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No differences in the number and type of adverse events were found, and no falls occurred after administration of THC.

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

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Inhaled cannabis demonstrated a dose dependent reduction in peripheral treatment-refractory neuropathic pain.

Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.

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Sativex appears to be a well-tolerated and useful add-on therapy in patients with spasticity due to multiple sclerosis.

Endocannabinoids control platelet activation and limit aggregate formation under flow.

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Activation of cannabinoid receptors by cannabis use reduces platelet activation and blood clotting.

Florida Low-THC Treatment Plan Presentation

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A treatment plan must be submitted quarterly to the University of Florida College of Pharmacy for research on the safety and efficacy of low-THC cannabis.

Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study

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Improvement in general health perception, social functioning, ability to work, physical pain and depression; weight gain; average rise in BMI; average Harvey-Bradshaw index was reduced

Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment.

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Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization

Impact of cannabis use during stabilization on methadone maintenance treatment.

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Symptoms of opiate withdrawal decrease in patients undergoing methadone maintenance treatment, who use cannabis.

Impact of Dronabinol on Quantitative Electroencephalogram (qEEG) Measures of Sleep in Obstructive Sleep Apnea Syndrome.

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THC treatment yielded a shift in EEG (electroencephalogram) power toward delta and theta frequencies and a strengthening of normal rhythms in the sleep.

Increased Blood Pressure Following Abrupt Cessation of Daily Cannabis Use.

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In 6 of 13 subjects blood pressure increased significantly after cessation of cannabis use.

Konikoff FM. Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study

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Cannabis produced significant clinical benefits in 10 of 11 patients with active Crohn’s disease.

Long-term effectiveness and safety of nabiximols (tetrahydrocannabinol/cannabidiol oromucosal spray) in clinical practice.

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Researchers found that “real-life data confirm the long-term effectiveness and tolerability of nabiximols [Sativex] for the treatment of resistant MSS [multiple sclerosis spasticity].

Low-dose vaporized cannabis significantly improves neuropathic pain

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Cannabis reduced pain. No difference in efficacy between the two doses.

Marijuana use in adults admitted to a Canadian epilepsy monitoring unit.

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Improvement in seizures, stress was decreased, sleep improved and memory/concentration was better

Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women.

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Cannabis use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women.

Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease.

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Patients find cannabis very helpful for symptom control.

Medical cannabis use in post-traumatic stress disorder: a naturalistic observational study.

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In most cases a significant improvement in quality of life and pain, with some positive changes in severity of posttraumatic stress disorder was observed.

Motion sickness, stress and the endocannabinoid system.

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Volunteers who developed acute motion sickness (n = 7) showed lower endocannabinoid levels during parabolic flights.

Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.

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Significant improvement by the cannabis extract Cannador of spasticity and pain.

Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers.

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The natural cannabinoid tetrahydrocannabivarin (THCV) altered the nerve response to pleasant and unpleasant stimuli in a way that it “suggests therapeutic activity in obesity.

Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia.

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In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects.

Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy

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About one third of children suffering from different forms of epilepsy experienced a more than 50 % reduction in seizures by the use of oral cannabis extracts.

Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience.

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Cannabis use “is perceived as highly effective” by some patients with advanced cancer.

Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting.

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Cannabis was superior to placebo in reducing nausea and vomiting in patients refractory to other medications

Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage.

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Cannabinoids-positive patients had lower median disease scores on admission

Profiles of medicinal cannabis patients attending compassion centers in rhode island.

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Most participants report that medicinal cannabis improves their pain symptomology.

PTSD contributes to teen and young adult cannabis use disorders.

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People with PTSD have a higher risk for cannabis use

Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study.

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Following aspects significantly decreased: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress

Safety of oral dronabinol during opioid withdrawal in humans

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40 mg of THC caused increased heart rate and anxiety, which made dose-reduction necessary

Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.

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Patients with epilepsy were able to control their seizures by the use of cannabis.

Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability

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No effect of a single low dose of THC on abdominal pain resulting from chronic pancreatitis in clinical study.

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial.

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Smoked cannabis was superior to placebo in reducing spasticity and pain.

Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas-possible role of Cannabis inhalation.

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Spontaneous regression of benign brain tumour may have been associated with cannabis use.

State-Legal Cannabis and Financial Institutions

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This White Paper covers how current laws create public safety hazards by discouraging financial institutions from working with legal cannabis businesses.

Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure.

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Subjective aggression significantly increased following aggression exposure in all groups while being sober.

Tardive Dystonia and the Use of Cannabis.

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Significant improvement by cannabis and dronabinol.

Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial.

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There were no effects on cramp intensity, number of cramps and fasciculation intensity.

Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial.

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No reduction in NPS by low-dose THC (3x1.5mg), though it is well-tolerated

The Cannabis Industry in the Trump Era

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This White Paper discusses the surprising 2016 election of Donald Trump and what it means for the cannabis businesses.

The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity.

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Cannabis reduces the stretch reflex in patients with multiple sclerosis

The medicinal use of cannabis and cannabinoids: an international survey on methods of intake.

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Preferred modes of use were smoking of cannabis (62.9 per cent), inhalation of cannabis with a vaporizer (23.6 per cent), oral use of cannabis in baked goods (7.9 per cent), oral use of cannabis as a tea (2.4 per cent),[...]

The Voice of the Cannabis Industry: 2016 Election Recap

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This PowerPoint covers how the 2016 election affects nine states who voted on the cannabis ballot on November 9, 2016.

Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report.

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A combination of baclofen injections into the cerebrospinal fluid and very low doses of the cannabis extract Sativex was highly effective.

Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation.

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Nabilone caused significant improvements in insomnia, nightmares, chronic pain and other symptoms in patients suffering from posttraumatic stress disorder (PTSD).

Use of cannabis among 139 cluster headache sufferers.

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Less than one third of self-reported users mention a relief of their attacks following inhalation.

Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD.

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Patients with high PTSD scores were more likely to use cannabis to improve sleep, and for coping reasons more generally.





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