There are more than 113 well-known cannabinoids you might be familiar with. Cannabidiol (CBD) is probably one of them. But are you familiar with Cannabidivarin, or CBDV?
The chemical structure of CBDV, is like CBD’s. It is also non-psychoactive, giving you medical benefits without getting you high.
This is great news, because it’s primarily the psychoactive aspect of cannabis which prevents it from being legalized by certain lawmakers, restricting research and access on cannabinoids despite the absence of psychoactive effects.
Despite this, we are continuously finding increasing varieties of cannabinoids that can heal like weed, but don’t get you high. Research and trials might be limited because of the law, but studies are still being conducted in spite of this. Researchers have even discovered attributes of CBDV that can relieveand stop convulsions.
The Lowdown on Cannabidivarin
Put on your lab coats, coz we’re about to get our science on! If this isn’t your thing, you can head straight to the next section.
We previously mentioned that CBDV’s chemical structure is like CBD’s. This means that it is CBD’s homolog. It has thirty stereoisomers and seven double bond isomers, similar to CBD. It also has two methylene bridges that shorten the side chain.
CBDV is non-psychoactive, which is another thing it has in common with CBD. You can’t get high off it, unlike with THC, which in increased levels can trigger panic attacks in people who are more sensitive. This means that you can still have the medical advantages of weed without the anxiety.
When you’re buying weed at dispensaries, finding strains that have CBDV is very uncommon. Most breeders go for strains that have a lot of terpenes and THC, because the typical customer is looking to get high. You should look for strains that are high in CBD, because they usually have CBDV too.
Cannabidivarin Used Therapeutically
Due to strict laws, there aren’t many studies on CBDV. Despite this, scientists are still researching on how CBD – like Green Roads pharmacist-formulated CBD oils – can be used to combat convulsions. In several studies, they have even used CBDV to treat the seizures and relieve the nausea that come with epilepsy.
In 2013, a clinical study proved that CBDV can lower how severe seizures induced by PTZ are. CBDV also increased the inactivity of the illness after the first seizure symptoms.
As a conclusion, the researchers stated that the findings they gathered from observations confirmed how at a molecular level, non-psychoactive CBD can serve as an anticonvulsant for seizures induced chemically. Additionally. CBDV is suitable for clinical development.
Researchers from Italy put up a team that conducted a study on CBD in 2014. They induced epilepsy systems in rats and observed how CBD and THC affected them. It was discovered that CBD and CBDV were able to interact with TRPV1, a receptor that producessensations while also regulating and detecting body temperatures.
To fight the process of epilepsy developing in a normal brain, the anticonvulsant Capsaicin must go after TRP channels. Both Capsaicin and CBDV can dephosphorylate TRPV1, as discovered by the team of researchers. It was proposed that the effects of CBDV on the TRP channels should be studied more to get more information about how it can be used as a treatment against convulsions.
Additionally, it was observed that the strength and length of seizures in rat brains were reduced by CBDV.
The British Journal of Pharmacology published a relevant study in 2013. It was an evaluation on how THCV and CBDV could potentially act as partial inverse agonists of CB1 receptors, inhibiting the nausea experienced by the test subjects.
As a conclusion, the researches stated that CBDV and THCV could reduce nausea potentially for therapy.
Cannabidivarin has been identified as a type of cannabinoid, among hundreds of other varieties. Similar to other CBDs, it can work with receptors of pain. Research studies have shown how it can also relieve nausea and prevent convulsions. CBDV products are being developed by GW Pharmaceuticals for trial and research purposes. The Pharmaceuticals group is currently studying how CBDV can be used as a treatment for epilepsy in adults. It should be legal if the CBDV is extracted from marijuana.
Source: Medical Marijuana Blog
View Original Post